1-dan master of the unyielding fist of Bayesian inference
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Introducing GPT-5

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We are introducing GPT‑5, our best AI system yet. GPT‑5 is a significant leap in intelligence over all our previous models, featuring state-of-the-art performance across coding, math, writing, health, visual perception, and more.
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clumma
21 hours ago
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Berkeley, CA
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Project Hyperion: Interstellar ship design competition

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Article URL: https://www.projecthyperion.org

Comments URL: https://news.ycombinator.com/item?id=44817539

Points: 344

# Comments: 302

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clumma
21 hours ago
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Berkeley, CA
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Genie 3: A new frontier for world models

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Article URL: https://deepmind.google/discover/blog/genie-3-a-new-frontier-for-world-models/

Comments URL: https://news.ycombinator.com/item?id=44798166

Points: 1468

# Comments: 483

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clumma
21 hours ago
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Berkeley, CA
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Ozempic Shows Anti-Aging Effects in First Clinical Trial, Reversing Biological Age by 3.1 Years

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submitted by /u/chillinewman to r/longevity
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clumma
2 days ago
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Berkeley, CA
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Why the US wants to put a nuclear reactor on the moon

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submitted by /u/TimesandSundayTimes to r/nuclearweapons
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clumma
2 days ago
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Berkeley, CA
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Reprogramming aging: genetically enhanced mesenchymal progenitor cells show systemic rejuvenation in primates

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FOXO3 is a well-established regulator of longevity, stress resistance, and stem-cell maintenance [4–6]. In a pioneering effort to reprogram aging-related genetic circuits, Liu’s group introduced two phospho-null mutations (S253A and S315A) into the FOXO3 locus, generating engineered human embryonic stem cells that, upon mesenchymal differentiation, gave rise to progenitor cells with enhanced stress resilience and self-renewal capacity—designated as senescence-resistant cells (SRCs). These cells exhibited enhanced proliferative potential, reduced secretion of senescence-associated secretory phenotype factors, and increased heterochromatin stability, all without evidence of transformation or tumorigenicity.

Administering SRCs intravenously to aged cynomolgus monkeys over a 44-week period led to a cascade of restorative changes. Compared to wild-type mesenchymal cells, SRCs more effectively reversed age-related changes across the brain, immune system, bone, skin, and reproductive tissues. Multi-modal assessments—behavioral, histological, transcriptomic, and methylomic—consistently indicated biological age reversal.

Notably, SRC-treated monkeys exhibited improved cognitive function, restored cortical architecture, and enhanced hippocampal connectivity. Bone density increased, periodontal degeneration was mitigated, and immune cell transcriptional profiles shifted toward a youthful state. At the molecular level, transcriptomic aging clocks showed an average reversal of 3.34 years with SRCs, while DNA methylation clocks corroborated these effects in multiple tissues. Furthermore, the authors observed the restoration of reproductive system health. In both male and female monkeys, SRC treatment reduced senescent markers, enhanced germ cell preservation, and reversed transcriptional aging clock across ovaries and testes. Single-cell transcriptomics revealed that oocytes, granulosa cells, and testicular germ cells responded particularly well, rejuvenating by up to 5–6 years. These findings offer new insights into addressing reproductive aging and fertility decline.

submitted by /u/GentlemenHODL to r/longevity
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clumma
2 days ago
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Berkeley, CA
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